CURRENT MEDICAL AND DRUG RESEARCH

Isolation of a new flavanone and evaluation of antidiabetic activity from Clematis buchananiana aerial parts

Fri, 25 Jun 2021 00:00:00 +0200

The present study aimed to explore the phytochemistry and antidiabetic activity of Clematis buchananiana DC. A new compound (1) characterized as 3-[(11’’-hydroxy, 3’’,6’’,10’’,10’’tetramethyldodecene)] 6-[(3’’’,4’’’,4’’’-trimethylhexene)] 5,7,2’,4’,6’pentahydroxy 8, 3’,5’ tri methyl flavanone was isolated from the aerial parts of the plant. The methanolic extract of the plant at a concentration of 1 mg/mL showed a 75.00% reduction in α-amylase and 73.13% in αglucosidase enzyme activity. Moreover, the methanolic extract at 100 mg/kg b.w. showed a significant decline in blood glucose levels of alloxan-induced diabetic rats both in acute and chronic studies. The results were compared with glibenclamide, an oral hypoglycemic agent, which was used as a positive control. The present study concludes that the plant has substantial antidiabetic potential in diabetic rats. These results are indicative and further studies are needed to revalidate the findings.

Self-reported effects of dysmenorrhea and its impact on health-related quality of life among female students of three tertiary institutions in Delta State of Nigeria

Peter A . Owonaro, Benedicta C. Uweru, John E. Arute, Joshua F. Eniojukan — Fri, 25 Jun 2021 00:00:00 +0200

Dysmenorrhea is a condition frequently reported by women of childbearing age. It may be accompanied by a number of symptoms. The severity of the symptoms of dysmenorrhea may significantly affect the professional activity of women, as well as their family and social life and also their emotional state. This study examined the self-reported effects of dysmenorrhea and its impact on the health-related quality of life of young women at the College of Education, Agbor, Delta State University Abraka and School of Health, Ufuoma. The research design was descriptive and cross-sectional employing the questionnaire as a research instrument. A total of 400 female students were randomly selected in the three institutions. SPSS Version 24 was used for the analysis. Most of the study groups were women between 16 and 27 years of age, with higher education, not married and not having children. The common symptoms experienced during menstruation were fatigue (26.3%), dizziness (15.3%) and headache (14.8%). On the impact on quality of life, 33.7%, 25.8%, 23.9% and 16.6% of all respondents always experienced negative effects in their social, career, sex and family lives respectively. The severity of menstrual cramps and diagnosis of health-associated risks among respondents from the various institutions were correlated in only Delta State University (p=0.022 and 0.002) and Delta-State School of Health (p=0.006 and 0.013) with effect on social and sex life of respondents respectively. Dysmenorrhea is an important health problem for adolescents, which adversely affects the daily activities and quality of life for adolescent women.

Therapeutic potential of medicinal herbs in the management of COVID-19

Rishabh ., Sonali Verma, Manni Rohilla, Anjali Garg, Randhir Singh — Fri, 25 Jun 2021 00:00:00 +0200

Medicinal plants have been in constant use since ancient times and are proven to be effective from time to time and even today, herbs are in great demand due to their high therapeutic values. The present paper highlights the usage of medicinal herbs against COVID-19 (SARS-CoV-2) which has brought on a global outbreak of severe respiratory disease. The Indian device of holistic medicine regarded as “Ayurveda” is playing a key role in controlling COVID-19 and its associated symptoms. Nutraceuticals and natural medicines can act as complementary preventive remedies for COVID-19. The literature survey presented several plant secondary metabolites that confirmed significant antiviral activity against SARS-CoV-2 through inhibiting the main proteins used in their pathogenesis and replication. This evaluation specializes in interpreting the capability of various secondary metabolites from medicinal herbs as healing alternatives, both as inhibitors of healing goals of SARS-CoV-2 or as blockers of viral debris access through host molecular receptors. The use of medicinal plants containing specific phytochemicals can be seen in offering a more secure and long-lasting answer for the population with lesser side effects. This review suggests certain Indian traditional medicinal plants as possible therapeutic targets exclusively against SARS-CoV-2.