Formulation and the Study of Finished Products used for Anginal Disease

  • Charanjeet . Singh Biyani Institute of Pharmaceutical Sciences, Jaipur, Rajasthan, India
  • Yashwant . . Biyani Institute of Pharmaceutical Sciences, Jaipur, Rajasthan, India
  • Anil K. Gupta Jaipur College of Pharmacy, Jaipur, Rajasthan, India
Keywords: Nitroglycerin, Sublingual dosage form, Superdisintegrant.


Congestive heart failure is a type of disease which is mainly observed due to the improper supply of blood to the heart. In this disease patient feels severe pain in the chest and may cause serious illness. Sudden treatment is needed in this disease to prevent any fatality. Nitroglycerin is the choice of drug for this disease. This study prepares a dosage form that can deliver the drug at a fast rate like a sublingual tablet of nitroglycerin. Sublingual dosage form was manufactured by direct compression method. For the formulation, multiple excipients like super disintegrants, sweeteners and lubricants were used. The finished dosage form was evaluated for different quality parameters. Optimum formulation was compared with the marketed product and kept on the accelerated stability study. Results were observed as satisfactory and comparable with the marketed product.