Cream for Tinea Pedis: Formulation and Validation using Extracts of Curcuma longa, Shorea robusta, and Madhuca indica

Abstract

Disease resistance has been linked in large part to the presence of antifungal chemicals in plant tissues. Fungal diseases that occur on the nails, hair, skin, and mucous membrane are referred to as superficial mycoses in tinea pedis, the toe get affected by Trichophyton species or with Epidermophyton floccosum which we call as fungal infection. Tinea pedis is widely spread in the Indian population, particularly in housemaids, farmers and athletes. Usually, there is irritation, erythema, edema, and inflammation at the spreading edge. All the drugs used are natural in origin and widely available in India, so it was decided to formulate the cream using their extracts. The cream is selected as a formulation for incorporation of the herbal drugs because the cream has an elegant appearance, patient acceptability, easy spreadability and ease of application. The local delivery of drugs is more feasible by topical application such as cream base. The rheological behavior of cream showed pseudoplastic flow and shear thinning property. The stability studies of cream state that the cream has good stability. The patient study reveals that the developed cream is tolerated by the patients, with most of the adverse effects being infrequent, mild and transient. Validation is achieved by measuring the attributes that is possible to quantify. Thus, a cream for tinea pedis was formulated using extracts of Curcuma longa, Shorea robusta and Madhuca indica. From the results, it is clear that the developed cream is effective in the treatment of tinea pedis.