Synthesis, Biological Evaluation and In-silico Studies of
3-((4-(6-(Substitutedphenyl)-2-Mercaptopyrimidin-4-Yl) Phenyl) Imino)-
1-((Dimethylamino) Methyl) Indolin-2-One

Perla . Swathi; S. . Raja

doi:10.25258/ijpqa.13.4.21

Perla . Swathi Department of Pharmaceutical Chemistry, Gitam Institute of Pharmacy, GITAM deemed to be University, Gandhi Nagar, Rushikonda, Visakhapatnam, Andhra Pradesh, India
S. . Raja Department of Pharmaceutical Chemistry, Gitam Institute of Pharmacy, GITAM deemed to be University, Gandhi Nagar, Rushikonda, Visakhapatnam, Andhra Pradesh, India

DOI: https://doi.org/10.25258/ijpqa.13.4.21

Keywords: Antitubercular activity, Chalcone, Insilico studies, Isatin, Pyrimidine.

Abstract

A novel isatin and pyrimidine prototype derivatives 3-((4-(6-(substitutedphenyl)-2-mercaptopyrimidin-4-yl)phenyl)imino)- 1-((dimethylamino)methyl)indolin-2-one were synthesized and designed from the intermediate chalcones. The produced components were characterized, anti-tubercular and antimicrobial screening was done by agar dilution and agar-cup plate methods, respectively. From the studies, it was revealed that derivatives 5e, 5h and 5i showed increased potency. Further in-silico studies were carried out by molecular docking with the interaction of target components 5a-5j within the Mycobacterium tuberculosis enoyl-acp reductase enzyme (1ZID), drug likeness, and pharmacokinetic parameters were measured by osiris property explorer and molinspiration online toolkit respectively.

Synthesis, Biological Evaluation and In-silico Studies of 3-((4-(6-(Substitutedphenyl)-2-Mercaptopyrimidin-4-Yl) Phenyl) Imino)- 1-((Dimethylamino) Methyl) Indolin-2-One

Abstract