Evaluation of Serum Vitamin D levels in Vitiligo Patients- A Case Control Study from Tertiary Care Hospital in North India
Keywords: Case control, Study, vitamin D, Vitiligo, Vitiligo.
AbstractBackground: Vitiligo is an acquired pigmentary condition characterized by white patches that affect the skin and the mucous membranes. Vitamin D is involved in the pathogenesis of various autoimmune conditions, including vitiligo. Its deficiency can be related to many such diseases and hence requires treatment with vitamin D analogues. We compared serum vitamin D levels of cases and controls in this case-control study. Objective: To assess the serum Vitamin D levels in vitiligo patients attending the clinics. Material and Methods: Seventy-two patients with vitiligo and the same number of healthy controls of age ranging from 18 to 60 years attending the outpatient department of our tertiary care centre were taken in the study, and the serum vitamin D levels were measured. Results were analyzed and compared with that of the control group. Statistical analysis was made to see the significance. Results: In this study, there was a highly significant difference in the mean serum vitamin D level (p less than 0.0001) between cases (17.51 ± 12.31 ng/mL) and controls (28.01 ± 15.84 ng/mL). We also compared the mean serum vitamin D level in cases and controls based on their demographic profile like age groups, gender, occupation, marital status, and in cases based on the disease-specific parameters like duration of disease, several patches involved, percentage of body surface area (BBA) involvement, type of vitiligo, progression of disease and family history of the disease. The mean level was decreased when these parameters were compared, but no strong statistical association was observed between the vitamin D levels and these parameters. Conclusion: The results of this study show a difference in the mean level of serum vitamin D in the cases as compared to the controls. However, our study emphasizes that more such studies have to be carried out to further explore the relationship of Vitamin D with vitiligo, which later may evolve as a possible therapeutic alternative.
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